Table 3.
Relationship between baseline periodontitis status and the incidence of NAFLD after a median follow-up of 7.7 years among participants of the Study of Health in Pomerania, 1997–2012
| Proportion of sites with clinical attachment level ≥3mm (n=2,526) | Proportion of sites with Probing pocket depth ≥4mm (n=2,623) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
|
|
|||||||||
| Rate | IRR (95% C.I) | P Value | IRD (95% C.I) | P Value | Rate | IRR (95% C.I) | P Value | IRD (95% C.I) | P Value | |
|
|
|
|||||||||
| Unadjusted | ||||||||||
| Edentulous | 17.6 | 0.61 (0.36, 1.02) | 0.1 | −11.4 (−21.3, −1.59) | 0.02 | 17.6 | 0.55 (0.34, 0.87) | 0.02 | −14.5 (−22.3, −6.65) | 0.0003 |
| No site | 29.0 | 1 [Reference] | NA | 0 [Reference] | NA | 32.1 | 1 [Reference] | NA | 0 [Reference] | NA |
| <30% of sites | 35.5 | 1.22 (0.88, 1.70) | 0.2 | 6.46 (−2.56, 15.5) | 0.2 | 35.3 | 1.10 (0.90, 1.35) | 0.3 | 3.28 (−2.72, 9.28) | 0.3 |
| ≥30% of sites | 34.6 | 1.19 (0.86, 1.65) | 0.3 | 5.56 (−2.98, 14.1) | 0.2 | 33.7 | 1.05 (0.75, 1.47) | 0.8 | 1.64 (−8.20, 11.5) | 0.7 |
| Adjusteda | ||||||||||
| Edentulous | 29.0 | 1.31 (0.27, 6.39) | 0.7 | 6.81 (−4.36, 18.0) | 0.2 | 28.7 | 0.92 (0.23, 3.64) | 0.9 | −2.58 (−12.0, 6.89) | 0.6 |
| No site | 22.1 | 1 [Reference] | NA | 0 [Reference] | NA | 31.3 | 1 [Reference] | NA | 0 [Reference] | NA |
| <30% of sites | 31.4 | 1.42 (0.96, 2.10) | 0.1 | 9.23 (0.45, 18.0) | .04 | 33.2 | 1.06 (0.86, 1.31) | 0.6 | 1.90 (−4.04, 7.83) | 0.5 |
| ≥30% of sites | 30.8 | 1.39 (0.94, 2.06) | 0.1 | 8.68 (0.38, 17.0) | .04 | 22.3 | 0.71 (0.49, 1.04) | 0.1 | −8.97 (−16.7, −1.22) | 0.02 |
| Adjustedb | ||||||||||
| Edentulous | 23.1 | 1.36 (0.33, 5.56) | 0.6 | 6.12 (−3.37, 15.6) | 0.2 | 23.0 | 0.89 (0.27, 2.97) | 0.8 | −2.72 (−11.1, 5.69) | 0.5 |
| No site | 17.0 | 1 [Reference] | NA | 0 [Reference] | NA | 25.7 | 1 [Reference] | NA | 0 [Reference] | NA |
| <30% of sites | 24.5 | 1.45 (0.92, 2.27) | 0.1 | 7.59 (0.26, 14.9) | 0.04 | 34.9 | 1.36 (1.01, 1.83) | 0.05 | 9.15 (3.59, 14.7) | 0.001 |
| ≥30% of sites | 29.4 | 1.74 (1.10, 2.74) | 0.02 | 12.5 (5.47, 19.5) | 0.0005 | 18.6 | 0.72 (0.48, 1.09) | 0.1 | −7.13 (−14.1, −0.12) | 0.05 |
| Adjustedc | ||||||||||
| Edentulous | 27.2 | 1.37 (0.26, 7.15) | 0.7 | 7.32 (−3.31, 17.9) | 0.2 | 25.2 | 0.91 (0.25, 3.34) | 0.9 | −2.47 (−11.3, 6.39) | 0.6 |
| No site | 19.9 | 1 [Reference] | NA | 0 [Reference] | NA | 27.6 | 1 [Reference] | NA | 0 [Reference] | NA |
| <30% of sites | 25.4 | 1.28 (0.84, 1.95) | 0.2 | 5.49 (−2.53, 13.5) | 0.2 | 42.3 | 1.53 (1.00, 2.35) | 0.05 | 14.6 (8.87, 20.4) | <0.0001 |
| ≥30% of sites | 31.8 | 1.60 (1.05, 2.43) | 0.03 | 11.9 (4.09, 19.6) | 0.003 | 21.3 | 0.77 (0.44, 1.33) | 0.3 | −6.34 (−13.7, 1.02) | 0.1 |
All estimates were averages from 40 rounds of multiple imputation combined using Rubin’s rule and the variance a function of the within and between completed dataset variances.
IRR-Incidence rate ratio; IRD-incidence rate difference
Rates and IRD are expressed per 1,000 person-years
Adjustment variables: age, sex, waist circumference, BMI, physical activity, alcohol consumption, education, smoking and diabetes
Adjusted for confounders only, using Inverse probability of exposure weights
Adjusted for confounders and censoring due to loss-to-follow-up (LTFU)
Adjusted for confounders and censoring from any reason (including LTFU, end of follow-up, excessive alcohol consumption, hepatitis diagnosis in past year, use of hepatotoxic medications)