Table 5.
Associations of weight loss and BMI (in the same model) with cause-specific mortality*
| Cardiovascular | Cancer | Respiratory | ||||
|---|---|---|---|---|---|---|
| sHR (95% CI) | P | sHR (95% CI) | P | sHR (95% CI) | P | |
| Model 1. Time-varying BMI and weight loss rate | ||||||
| BMI (kg/m2) | ||||||
| <20 | 1.16 (0.26, 5.13) | 0.84 | 1.27 (0.69, 2.31) | 0.44 | 2.96 (1.29, 6.78) | 0.01 |
| 20–25 | Referent | - | Referent | - | Referent | - |
| 25–30 | 0.58 (0.39, 0.87) | 0.009 | 0.90 (0.39, 2.10) | 0.69 | 0.91 (0.55, 1.52) | 0.73 |
| >30 | 0.76 (0.33, 1.77) | 0.53 | 0.73 (0.37, 1.43) | 0.36 | 0.49 (0.23, 1.02) | 0.06 |
| Weight loss rate (kg/m2/year) | ||||||
| None | Referent | - | Referent | - | Referent | - |
| 0–2 | 0.97 (0.69, 1.37) | 0.88 | 0.79 (0.52, 1.20) | 0.27 | 0.76 (0.46, 1.24) | 0.27 |
| 2–3 | 1.17 (0.63, 2.17) | 0.62 | 1.16 (0.66, 2.04) | 0.60 | 0.71 (0.34, 1.48) | 0.36 |
| >3 | 2.15 (1.50, 3.08) | <0.001 | 2.20 (1.02, 4.73) | 0.04 | 1.06 (0.56, 1.98) | 0.86 |
| Model 2. Time-varying BMI and percent weight loss | ||||||
| BMI (kg/m2) | ||||||
| <20 | 1.21 (0.29, 5.02) | 0.80 | 1.28 (0.62, 2.66) | 0.51 | 2.69 (1.09, 6.60) | 0.03 |
| 20–25 | Referent | - | Referent | - | Referent | - |
| 25–30 | 0.63 (0.44, 0.90) | 0.01 | 0.94 (0.42, 2.08) | 0.87 | 1.00 (0.58, 1.74) | 0.99 |
| >30 | 0.86 (0.41, 1.80) | 0.67 | 0.77 (0.41, 1.46) | 0.42 | 0.56 (0.27, 1.16) | 0.12 |
| Weight loss percent | ||||||
| None | Referent | - | Referent | - | Referent | - |
| <5 | 1.39 (1.08, 1.80) | 0.01 | 0.89 (0.44, 1.82) | 0.76 | 1.06 (0.67, 1.67) | 0.80 |
| 5–10 | 1.31 (0.93, 1.86) | 0.13 | 1.21 (0.77, 1.89) | 0.40 | 1.50 (0.78, 2.86) | 0.22 |
| >10 | 2.09 (1.00, 4.39) | 0.05 | 1.71 (0.88, 3.32) | 0.11 | 1.54 (0.71, 3.32) | 0.27 |
*
Covariates: age, sex, race, smoking status, comorbidity, MDHAQ, DAS28
Abbreviations: BMI = body mass index; sHR = sub-hazard ratio; CI = confidence interval