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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: J Allergy Clin Immunol. 2017 Apr 20;141(1):257–268.e6. doi: 10.1016/j.jaci.2017.03.032

Figure 7.

Figure 7

Effect of MEK, Jak and STAT5 inhibitors on steroid resistance of BAL ILC2s. BAL cells were cultured for 3 days with vehicle, Dex, the MEK inhibitor Trametinib with and without Dex (A), the Jak3 inhibitor Tofacitinib with and without Dex (B) or the STAT5 inhibitor Pimozide with and without Dex (C&D). The effect of Dex and the inhibitors with and without Dex on BAL IL5+ ILC2s (A, B & D) is shown. The flow cytogram in C shows the effect of Pimozide on pSTAT5. Each symbol represents a single asthma patients (n=5–7). P values were calculated using the non-parametric Kruskal Wallis test.