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Differentiation of SIAD from renal salt wasting syndrome (RSWS) [modified from Ref. (18)].
| SIAD | RSWS | |
|---|---|---|
| Volume status | Euvolemia | Hypovolemia |
| Urine output | Low | High |
| Central venous pressure | Normal | Low |
| Urea and creatinine | Low/normal | High |
| Uric acid | Low | Low |
| Plasma osmolality | Decreased | Decreased |
| Urine Na concentration (mmol/l) | >20* | >20* |
| Plasma renin activity, aldosterone | Low | High |
*Urine Na concentration may be <20mmol/l when sodium is restricted in the diet.
