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The time course of paw withdrawal threshold (PWT) in naive, sham and cancer-induced bone pain (CIBP) rats. The ipsilateral PWTs were significantly decreased from day 7 to day 21 after surgery in CIBP rats (***p < 0.001 compared with the naive group, n = 6 in each group). In contrast, naive and sham rats showed no significant change in PWTs during the 21-day observation period.
