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Preventive effect of early treatment with Tempol on the development of cancer-induced bone pain (CIBP). Tempol (200 mg/kg, i.p.) was given once daily from day 1 to day 5 after surgery. The behavioral tests were conducted at baseline and day 7. CIBP rats treated with Tempol and vehicle showed significantly decreased PWTs at day 7 after surgery. Moreover, no significant difference was observed between the groups (CIBP + Vehicle vs CIBP + Tempol, p > 0.05).
