Nomenclature	TLR1	TLR2	TLR3	TLR4	TLR5
HGNC, UniProt	TLR1, Q15399	TLR2, O60603	TLR3, O15455	TLR4, O00206	TLR5, O60602
Agonists	–	compound 13 [91], peptidoglycan [163, 205]	poly(I:C) [5]	LPS [150], paclitaxel [85] – Mouse	flagellin [67]
Selective antagonists	–	–	–	resatorvid [78]	–
Comments	Functions as a heterodimer with TLR2 in detection of triacylated lipoproteins. Activated by the synthetic analogue Pam3CSK4.	Functions as a heterodimer with either TLR1 or TLR6 in the detection of triacylated and diacylated lipopeptides respectively. TLR1/2 and 2/6 heterodimers can be activated by the synthetic lipopeptides Pam3CSK4 and Pam2CSK4 respectively. There is some debate in the field as to whether or not peptidoglycan is a direct agonist of TLR2, or whether the early studies reporting this contained contaminating lipoproteins.	Involved in endosomal detection of dsRNA; pro‐inflammatory.	eritoran (E5564) is a lipid A analogue, which has been described as a TLR4 antagonist [79]. TLR4 signals in conjunction with the co‐factor MD‐2 (LY96).	Involved in the detection of bacterial flagellin; pro‐inflammatory.