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. 2017 Oct 21;174(Suppl Suppl 1):S225–S271. doi: 10.1111/bph.13876
Nomenclature fibroblast growth factor receptor 1 fibroblast growth factor receptor 2 fibroblast growth factor receptor 3 fibroblast growth factor receptor 4
HGNC, UniProt FGFR1, P11362 FGFR2, P21802 FGFR3, P22607 FGFR4, P22455
EC number 2.7.10.1 2.7.10.1 2.7.10.1 2.7.10.1
Common abreviation FGFR1 FGFR2 FGFR3 FGFR4
Endogenous ligands FGF‐1 (FGF1, P05230), FGF‐2 (FGF2, P09038), FGF‐4 (FGF4, P08620) >FGF‐5 (FGF5, P12034), FGF‐6 (FGF6, P10767) [146] FGF‐1 (FGF1, P05230) >FGF‐4 (FGF4, P08620), FGF‐7 (FGF7, P21781), FGF‐9 (FGF9, P31371) >FGF‐2 (FGF2, P09038), FGF‐6 (FGF6, P10767) [146] FGF‐1 (FGF1, P05230), FGF‐2 (FGF2, P09038), FGF‐9 (FGF9, P31371) >FGF‐4 (FGF4, P08620), FGF‐8 (FGF8, P55075) [146] FGF‐1 (FGF1, P05230), FGF‐2 (FGF2, P09038), FGF‐4 (FGF4, P08620), FGF‐9 (FGF9, P31371) >FGF‐6 (FGF6, P10767), FGF‐8 (FGF8, P55075) [146]
Sub/family‐selective inhibitors LY2874455 (pIC50 8.6) [205] LY2874455 (pIC50 8.6) [205] LY2874455 (pIC50 8.2) [205] LY2874455 (pIC50 8.2) [205]
Selective inhibitors BLU9931 (pIC50 8.5) [75]
Agonists palifermin