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. 2017 Oct 21;174(Suppl Suppl 1):S225–S271. doi: 10.1111/bph.13876
Nomenclature neurotrophic receptor tyrosine kinase 1 neurotrophic receptor tyrosine kinase 2 neurotrophic receptor tyrosine kinase 3
HGNC, UniProt NTRK1, P04629 NTRK2, Q16620 NTRK3, Q16288
EC number 2.7.10.1 2.7.10.1 2.7.10.1
Common abreviation trkA trkB trkC
Endogenous ligands NGF (NGF, P01138) >neurotrophin‐3 (NTF3, P20783) BDNF (BDNF, P23560), neurotrophin‐4 (NTF4, P34130) >neurotrophin‐3 (NTF3, P20783) neurotrophin‐3 (NTF3, P20783)
Inhibitors compound 2c (pIC50 8.9) [189], milciclib (pIC50 7.3) [14]
Sub/family‐selective inhibitors AZD1332 (pIC50>8.3) [9], GNF‐5837 (pIC50 8) [2] AZD1332 (pIC50>8.3) [9], GNF‐5837 (pIC50 8.1) [2] AZD1332 (pIC50>8.3) [9], GNF‐5837 (pIC50 8.1) [2]