Nomenclature | neurotrophic receptor tyrosine kinase 1 | neurotrophic receptor tyrosine kinase 2 | neurotrophic receptor tyrosine kinase 3 |
HGNC, UniProt | NTRK1, P04629 | NTRK2, Q16620 | NTRK3, Q16288 |
EC number | 2.7.10.1 | 2.7.10.1 | 2.7.10.1 |
Common abreviation | trkA | trkB | trkC |
Endogenous ligands | NGF (NGF, P01138) >neurotrophin‐3 (NTF3, P20783) | BDNF (BDNF, P23560), neurotrophin‐4 (NTF4, P34130) >neurotrophin‐3 (NTF3, P20783) | neurotrophin‐3 (NTF3, P20783) |
Inhibitors | compound 2c (pIC50 8.9) [189], milciclib (pIC50 7.3) [14] | – | – |
Sub/family‐selective inhibitors | AZD1332 (pIC50>8.3) [9], GNF‐5837 (pIC50 8) [2] | AZD1332 (pIC50>8.3) [9], GNF‐5837 (pIC50 8.1) [2] | AZD1332 (pIC50>8.3) [9], GNF‐5837 (pIC50 8.1) [2] |