Nomenclature | CD27 | CD30 | 4‐1BB | death receptor 4 | death receptor 5 | decoy receptor 1 | decoy receptor 2 |
Systematic nomenclature | TNFRSF7 | TNFRSF8 | TNFRSF9 | TNFRSF10A | TNFRSF10B | TNFRSF10C | TNFRSF10D |
HGNC, UniProt | CD27, P26842 | TNFRSF8, P28908 | TNFRSF9, Q07011 | TNFRSF10A, O00220 | TNFRSF10B, O14763 | TNFRSF10C, O14798 | TNFRSF10D, Q9UBN6 |
Adaptor proteins | TRAF2, SIVA | TRAF1, TRAF2, TRAF3, TRAF5 | TRAF1, TRAF2, TRAF3 | FADD | FADD | – | – |
Common abreviation | – | – | – | DR4 | DR5 | – | – |
Endogenous ligands | CD70 (CD70, P32970) | CD30 ligand (TNFSF8, P32971) | 4‐1BB ligand (TNFSF9, P41273) | TRAIL (TNFSF10, P50591) | – | – | – |
Endogenous agonists | – | – | – | – | TRAIL (TNFSF10, P50591) [208] | – | – |
Agonists | – | – | – | SC‐67655 [77] | – | – | – |
Antibodies | – | brentuximab vedotin (Inhibition) | – | – | tigatuzumab (Agonist) (pK d∼8.5) [208] | – | – |
Comments | – | – | – | – | – | Decoy receptor for TRAIL (TNFSF10, P50591). | Decoy receptor for TRAIL (TNFSF10, P50591). |