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. 2017 Oct 21;174(Suppl Suppl 1):S225–S271. doi: 10.1111/bph.13876
Nomenclature CD27 CD30 4‐1BB death receptor 4 death receptor 5 decoy receptor 1 decoy receptor 2
Systematic nomenclature TNFRSF7 TNFRSF8 TNFRSF9 TNFRSF10A TNFRSF10B TNFRSF10C TNFRSF10D
HGNC, UniProt CD27, P26842 TNFRSF8, P28908 TNFRSF9, Q07011 TNFRSF10A, O00220 TNFRSF10B, O14763 TNFRSF10C, O14798 TNFRSF10D, Q9UBN6
Adaptor proteins TRAF2, SIVA TRAF1, TRAF2, TRAF3, TRAF5 TRAF1, TRAF2, TRAF3 FADD FADD
Common abreviation DR4 DR5
Endogenous ligands CD70 (CD70, P32970) CD30 ligand (TNFSF8, P32971) 4‐1BB ligand (TNFSF9, P41273) TRAIL (TNFSF10, P50591)
Endogenous agonists TRAIL (TNFSF10, P50591) [208]
Agonists SC‐67655 [77]
Antibodies brentuximab vedotin (Inhibition) tigatuzumab (Agonist) (pK d∼8.5) [208]
Comments Decoy receptor for TRAIL (TNFSF10, P50591). Decoy receptor for TRAIL (TNFSF10, P50591).