Nomenclature | Navi2.1 |
HGNC, UniProt | NALCN, Q8IZF0 |
Activators | Constitutively active [52], or activated downstream of Src family tyrosine kinases (SFKs) [53, 96]; positively modulated by decreased extracellular Ca2+ concentration [54] |
Channel blockers | Gd3+ (pIC50 5.6), Cd2+ (pIC50 3.8), Co2+ (pIC50 3.6), verapamil (pIC50 3.4) |
Functional Characteristics | γ = 27 pS (by fluctuation analysis), PNa/PCs = 1.3, PK/PCs = 1.2, PCa/PCs = 0.5, linear current voltage‐relationship, voltage‐independent and non‐inactivating |