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. 2017 Oct 21;174(Suppl Suppl 1):S195–S207. doi: 10.1111/bph.13881
Nomenclature Navi2.1
HGNC, UniProt NALCN, Q8IZF0
Activators Constitutively active [52], or activated downstream of Src family tyrosine kinases (SFKs) [53, 96]; positively modulated by decreased extracellular Ca2+ concentration [54]
Channel blockers Gd3+ (pIC50 5.6), Cd2+ (pIC50 3.8), Co2+ (pIC50 3.6), verapamil (pIC50 3.4)
Functional Characteristics γ = 27 pS (by fluctuation analysis), PNa/PCs = 1.3, PK/PCs = 1.2, PCa/PCs = 0.5, linear current voltage‐relationship, voltage‐independent and non‐inactivating