Nomenclature	ClC‐5	ClC‐6	ClC‐7
HGNC, UniProt	CLCN5, P51795	CLCN6, P51797	CLCN7, P51798
Channel blockers	–	DIDS (pIC50 3)	DIDS (pIC50 4.4) [90], NS5818 (pIC50 4.3) [90], NPPB (pIC50 3.8) [90]
Functional Characteristics	Cl‐/H+ antiporter (2Cl‐:1H+) [73, 87, 94, 109]; extreme outward rectification; voltage‐dependent gating with midpoint of activation of 116.0 mV; rapid activation and deactivation; potentiated and inhibited by intracellular and extracellular acidosis, respectively; ATP binding to cytoplasmic cystathionine β‐synthetase related (CBS) domains activates ClC‐5	Cl‐/H+ antiporter (2Cl‐:1H+) [62]; outward rectification, rapid activation and deactivation	Cl‐/H+ antiporter (2Cl‐:1H+) [34, 48, 90]; strong outward rectification; voltage‐dependent gating with a threshold more positive than ∼ + 20 mV; very slow activation and deactivation
Comments	insensitive to the channel blockers DIDS (1 mM), diphenylamine‐2‐carboxylic acid (1 mM), 9‐anthroic acid (2 mM), NPPB (0.5 mM) and niflumic acid (1 mM)	–	active when co‐expressed with Ostm1