Nomenclature	CaCC
HGNC, UniProt	ANO1, Q5XXA6
Endogenous activators	intracellular Ca2+
Selective inhibitors	crofelemer (pIC50 5.2) [99]
Endogenous channel blockers	Ins(3,4,5,6)P4
Channel blockers	9‐anthroic acid, DCDPC, DIDS, NPPB, SITS, flufenamic acid, fluoxetine, mibefradil, niflumic acid, tannic acid
Functional Characteristics	γ = 0.5–5 pS; permeability sequence, SCN‐> NO3 ‐> I‐> Br‐> Cl‐> F‐; relative permeability of SCN‐:Cl‐ ∼ 8. I‐:Cl‐ ∼ 3, aspartate:Cl‐ ∼ 0.15, outward rectification (decreased by increasing [Ca2+]i); sensitivity to activation by [Ca2+]i decreased at hyperpolarized potentials; slow activation at positive potentials (accelerated by increasing [Ca2+]i); rapid deactivation at negative potentials, deactivation kinetics modulated by anions binding to an external site; modulated by redox status