| Nomenclature | farnesyl diphosphate synthase | squalene synthase | squalene monooxygenase | lanosterol synthase |
| HGNC, UniProt | FDPS, P14324 | FDFT1, P37268 | SQLE, Q14534 | LSS, P48449 |
| EC number | 2.5.1.10: geranyl diphosphate + isopentenyl diphosphate ‐>trans,trans‐farnesyl diphosphate + diphosphate 2.5.1.1: dimethylallyl diphosphate + isopentenyl diphosphate = geranyl diphosphate + diphosphate | 2.5.1.21: 2trans,trans‐farnesyl diphosphate ‐>presqualene diphosphate + diphosphate presqualene diphosphate + NAD(P)H + H+ ‐>squalene + diphosphate + NAD(P)+ | 1.14.13.132: H+ + NADPH + O2 + squalene = H2O + NADP+ + (S)‐2,3‐epoxysqualene | 5.4.99.7: (S)‐2,3‐epoxysqualene = lanosterol |
| Cofactors | – | NADPH | – | – |
| Inhibitors | risedronate (pIC50 8.4) [33], zoledronic acid (pK i 7.1) [129], alendronate (pIC50 6.3) [33] | zaragozic acid A (pK i 10.1) [34] – Rat, zaragozic acid A (pIC50 9.2) [530] | – | |
| Selective inhibitors | ibandronic acid (pK i 6.7) [129], pamidronic acid (pIC50 6.7) [129] | – | – | – |
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