| Nomenclature | dihydrofolate reductase | dihydroorotate dehydrogenase (quinone) | inosine monophosphate dehydrogenase 1 | inosine monophosphate dehydrogenase 2 | xanthine dehydrogenase |
| HGNC, UniProt | DHFR, P00374 | DHODH, Q02127 | IMPDH1, P20839 | IMPDH2, P12268 | XDH, P47989 |
| EC number | 1.5.1.3 | 1.3.5.2 | 1.1.1.205 | 1.1.1.205 | 1.17.1.4 |
| Inhibitors | pemetrexed (pK i 8.1) [171, 474], pralatrexate (pK i 7.3) [244] | teriflunomide (pK i 7.5) [214], leflunomide (pK i 4.9) [397] | mycophenolic acid (pIC50 7.7) [376], ribavirin (pIC50 5.6–6) [572], thioguanine [132, 546] | mycophenolic acid (pIC50 7.7) [376], ribavirin (pIC50 5.6–6) [572], thioguanine [132, 546] | febuxostat (pK i 9.9) [387] – Bovine, allopurinol (pK i 5.2) [36] |
| Selective inhibitors | methotrexate (pK i 8.9) [446] | – | – | – | – |
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