| Nomenclature | sphingosine kinase 1 | sphingosine kinase 2 |
| HGNC, UniProt | SPHK1, Q9NYA1 | SPHK2, Q9NRA0 |
| EC number | 2.7.1.91: sphingosine + ATP = sphingosine 1‐phosphate + ADP ATP + sphinganine = sphinganine 1‐phosphate + ADP | 2.7.1.91: sphingosine + ATP = sphingosine 1‐phosphate + ADP ATP + sphinganine = sphinganine 1‐phosphate + ADP |
| Common abreviation | SPHK1 | SPHK2 |
| Cofactors | Mg2+ [469] | Mg2+ |
| Sub/family‐selective inhibitors | SKI‐II (pIC50 6.3) [156] | – |
| Selective inhibitors | PF‐543 (pIC8.7) [556], | ABC294640 (pK i 5) [157], ROMe (pIC50 4.6) [304] |
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