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. 2017 Oct 21;174(Suppl Suppl 1):S272–S359. doi: 10.1111/bph.13877
Nomenclature phosphodiesterase 7A phosphodiesterase 7B phosphodiesterase 8A phosphodiesterase 8B
HGNC, UniProt PDE7A, Q13946 PDE7B, Q9NP56 PDE8A, O60658 PDE8B, O95263
Common abreviation PDE7A PDE7B PDE8A PDE8B
Rank order of affinity cyclic AMPcyclic GMP [353] cyclic AMPcyclic GMP [176] cyclic AMPcyclic GMP [146] cyclic AMPcyclic GMP [214]
Inhibitors crisaborole (pIC50 6.1) [8] BRL50481 (pIC50 4.9) [9]
Selective inhibitors BRL50481 (pIC50 6.7–6.8) [9, 486] dipyridamole (pIC50 5.7–6) [179, 455], SCH51866 (pIC50 5.8) [455] dipyridamole (pIC50 5.1) [146] dipyridamole (pIC50 4.3) [214]
Comments PDE7A appears to be membrane‐bound or soluble for PDE7A1 and 7A2 splice variants, respectively