Nomenclature | phosphodiesterase 7A | phosphodiesterase 7B | phosphodiesterase 8A | phosphodiesterase 8B |
HGNC, UniProt | PDE7A, Q13946 | PDE7B, Q9NP56 | PDE8A, O60658 | PDE8B, O95263 |
Common abreviation | PDE7A | PDE7B | PDE8A | PDE8B |
Rank order of affinity | cyclic AMP≫cyclic GMP [353] | cyclic AMP≫cyclic GMP [176] | cyclic AMP≫cyclic GMP [146] | cyclic AMP≫cyclic GMP [214] |
Inhibitors | crisaborole (pIC50 6.1) [8] | BRL50481 (pIC50 4.9) [9] | – | – |
Selective inhibitors | BRL50481 (pIC50 6.7–6.8) [9, 486] | dipyridamole (pIC50 5.7–6) [179, 455], SCH51866 (pIC50 5.8) [455] | dipyridamole (pIC50 5.1) [146] | dipyridamole (pIC50 4.3) [214] |
Comments | PDE7A appears to be membrane‐bound or soluble for PDE7A1 and 7A2 splice variants, respectively | – | – | – |