Nomenclature | CYP4A11 | CYP4F2 | CYP4F3 | CYP4F8 |
HGNC, UniProt | CYP4A11, Q02928 | CYP4F2, P78329 | CYP4F3, Q08477 | CYP4F8, P98187 |
EC number | 1.14.15.3 | 1.14.13.30 | 1.14.13.30 | 1.14.14.1 |
Inhibitors | – | 17‐octadecynoic acid (pK i 5.9) [470] | – | – |
Comments | Converts lauric acid to 12‐hydroxylauric acid. | Responsible for ω‐hydroxylation of LTB4, LXB4 [359], and tocopherols, including vitamin E [491] | Responsible for ω‐hydroxylation of LTB4, LXB4 [359], and polyunsaturated fatty acids [143, 207] | Converts PGH2 to 19‐hydroxyPGH2 [60] and 8,9‐EET or 11,12‐EET to 18‐hydroxy‐8,9‐EET or 18‐hydroxy‐11,12‐EET [378]. |