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. 2017 Oct 21;174(Suppl Suppl 1):S272–S359. doi: 10.1111/bph.13877
Nomenclature CYP4A11 CYP4F2 CYP4F3 CYP4F8
HGNC, UniProt CYP4A11, Q02928 CYP4F2, P78329 CYP4F3, Q08477 CYP4F8, P98187
EC number 1.14.15.3 1.14.13.30 1.14.13.30 1.14.14.1
Inhibitors 17‐octadecynoic acid (pK i 5.9) [470]
Comments Converts lauric acid to 12‐hydroxylauric acid. Responsible for ω‐hydroxylation of LTB4, LXB4 [359], and tocopherols, including vitamin E [491] Responsible for ω‐hydroxylation of LTB4, LXB4 [359], and polyunsaturated fatty acids [143, 207] Converts PGH2 to 19‐hydroxyPGH2 [60] and 8,9‐EET or 11,12‐EET to 18‐hydroxy‐8,9‐EET or 18‐hydroxy‐11,12‐EET [378].