Nomenclature	N‐Acylphosphatidylethanolamine‐phospholipase D	Fatty acid amide hydrolase	Fatty acid amide hydrolase‐2	N‐Acylethanolamine acid amidase
HGNC, UniProt	NAPEPLD, Q6IQ20	FAAH, O00519	FAAH2, Q6GMR7	NAAA, Q02083
EC number	–	3.5.1.99: anandamide + H2O <=> arachidonic acid + ethanolamine oleamide + H2O <=> oleic acid + NH3 The enzyme is responsible for the catabolism of neuromodulatory fatty acid amides, including anandamide and oleamide: anandamide + H2O <=> arachidonic acid + ethanolamine oleamide + H2O <=> oleic acid + NH3	3.5.1.99: anandamide + H2O <=> arachidonic acid + ethanolamine oleamide + H2O <=> oleic acid + NH3 The enzyme is responsible for the catabolism of neuromodulatory fatty acid amides, including anandamide and oleamide: anandamide + H2O <=> arachidonic acid + ethanolamine oleamide + H2O <=> oleic acid + NH3	3.5.1.‐
Common abreviation	NAPE‐PLD	FAAH	FAAH2	NAAA
Rank order of affinity	–	anandamide>oleamide>N‐oleoylethanolamide>N‐palmitoylethanolamine [563]	oleamide>N‐oleoylethanolamide>anandamide>N‐palmitoylethanolamine [563]	N‐palmitoylethanolamine>MEA>SEA≥N‐oleoylethanolamide>anandamide [539]
Selective inhibitors	–	JNJ1661010 (pIC50 7.8) [264], PF750 (pIC50 6.3–7.8) [5], OL135 (pIC50 7.4) [563], URB597 (pIC50 6.3–7) [563], PF3845 (pIC50 6.6) [6]	OL135 (pIC50 7.9–8.4) [261, 563], URB597 (pIC50 7.5–8.3) [261, 563]	S‐OOPP (pIC50 6.4) [489] – Rat, CCP (pIC50 5.3) [535]
Comments	NAPE‐PLD activity appears to be enhanced by polyamines in the physiological range [311], but fails to transphosphatidylate with alcohols [408] unlike phosphatidylcholine‐specific phospholipase D.	–	The FAAH2 gene is found in many primate genomes, marsupials, and other distantly related vertebrates, but not a variety of lower placental mammals, including mouse and rat [563].	–