| Nomenclature | Diacylglycerol lipase α | Diacylglycerol lipase β | Monoacylglycerol lipase | αβ‐Hydrolase 6 |
| HGNC, UniProt | DAGLA, Q9Y4D2 | DAGLB, Q8NCG7 | MGLL, Q99685 | ABHD6, Q9BV23 |
| EC number | 3.1.1.‐ | 3.1.1.‐ | 3.1.1.23 | 3.1.1.23 |
| Common abreviation | DAGLα | DAGLβ | MAGL | ABHD6 |
| Endogenous substrates | diacylglycerol | diacylglycerol | 2‐oleoyl glycerol = 2‐arachidonoylglycerol≫anandamide [181] | 1‐arachidonoylglycerol >2‐arachidonoylglycerol> 1‐oleoylglycerol >2‐oleoyl glycerol [375] |
| Selective inhibitors | orlistat (pIC50 7.2) [40], RHC80267 (pIC50 4.2) [255] | orlistat (pIC50 7) [40], RHC80267 | JJKK 048 (pIC50 9.3) [1], KML29 (pIC50 8.5) [77], JZL184 (pIC50 8.1) [314] | WWL70 (pIC50 7.2) [299], WWL123 (pIC50 6.4) [21] |
| Comments | – | – | – | WWL70 has also been suggested to have activity at oxidative metabolic pathways independent of ABHD6 [513]. |
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.