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. 2017 Oct 21;174(Suppl Suppl 1):S17–S129. doi: 10.1111/bph.13878
Nomenclature DP 1 receptor DP 2 receptor
HGNC, UniProt PTGDR, Q13258 PTGDR2, Q9Y5Y4
Potency order of endogenous ligands PGD 2>PGE 1PGE 2>PGF 2α>PGI 2, thromboxane A 2 PGD 2PGF 2α, PGE 2>PGI 2, thromboxane A 2
Selective agonists BW 245C [173, 2133, 2134], L‐644,698 [2133, 2134] 15(R)‐15‐methyl‐PGD 2 [747, 1366, 1889]
Antagonists fevipiprant (pK d 9) [1908, 1909], ramatroban (pK i 7.4) [1889]
Selective antagonists laropiprant (pK i 10.1) [1882], BWA868C (pK i 8.6–9.3) [173, 640, 2133], ONO‐AE3‐237 (pK i 7.7) [796, 1974, 1976] CAY 10471 (pIC50 8.9) [1684, 2003]
Labelled ligands [3 H]PGD 2 (Agonist) [2119, 2133] [3 H]PGD 2 (Agonist) [1280, 1790]