Nomenclature |
DP
1 receptor |
DP
2 receptor |
HGNC, UniProt |
PTGDR, Q13258
|
PTGDR2, Q9Y5Y4
|
Potency order of endogenous ligands |
PGD
2>PGE
1≫PGE
2>PGF
2α>PGI
2, thromboxane A
2
|
PGD
2≫PGF
2α, PGE
2>PGI
2, thromboxane A
2
|
Selective agonists |
BW 245C [173, 2133, 2134], L‐644,698 [2133, 2134] |
15(R)‐15‐methyl‐PGD
2 [747, 1366, 1889] |
Antagonists |
– |
fevipiprant (pK
d 9) [1908, 1909], ramatroban (pK
i 7.4) [1889] |
Selective antagonists |
laropiprant (pK
i 10.1) [1882], BWA868C (pK
i 8.6–9.3) [173, 640, 2133], ONO‐AE3‐237 (pK
i 7.7) [796, 1974, 1976] |
CAY 10471 (pIC50 8.9) [1684, 2003] |
Labelled ligands |
[3
H]PGD
2 (Agonist) [2119, 2133] |
[3
H]PGD
2 (Agonist) [1280, 1790] |