Nomenclature	GPR83	GPR84	GPR85	GPR87	GPR88	GPR101
HGNC, UniProt	GPR83, Q9NYM4	GPR84, Q9NQS5	GPR85, P60893	GPR87, Q9BY21	GPR88, Q9GZN0	GPR101, Q96P66
Endogenous agonists	–	–	–	LPA [1401, 1911]	–	–
Agonists	PEN {Mouse} [655] – Mouse, Zn 2+ [1409] – Mouse	decanoic acid [1854, 2067], undecanoic acid [2067], lauric acid [2067]	–	–		–
Comments	One isoform has been implicated in the induction of CD4(+) CD25(+) regulatory T cells (Tregs) during inflammatory immune responses [731]. The extracellular N‐terminal domain is reported as an intramolecular inverse agonist [1410].	Medium chain free fatty acids with carbon chain lengths of 9‐14 activate GPR84 [1901, 2067]. A surrogate ligand for GPR84, 6‐n‐octylaminouracil has also been proposed [1901]. See review [414] for discussion of classification. Mutational analysis and molecular modelling of GPR84 has been reported [1463].	Proposed to regulate hippocampal neurogenesis in the adult, as well as neurogenesis‐dependent learning and memory [319].	–	Gene disruption results in altered striatal signalling [1203]. Small molecule agonists have been reported [151].	Mutations in GPR101 have been linked to gigantism and acromegaly [1982].