Nomenclature	LGR5	LGR6	MAS1	MAS1L
HGNC, UniProt	LGR5, O75473	LGR6, Q9HBX8	MAS1, P04201	MAS1L, P35410
Endogenous agonists	R‐spondin‐2 (RSPO2, Q6UXX9) [277], R‐spondin‐1 (RSPO1, Q2MKA7) [277], R‐spondin‐3 (RSPO3, Q9BXY4) [277], R‐spondin‐4 (RSPO4, Q2I0M5) [277]	R‐spondin‐1 (RSPO1, Q2MKA7) [277, 426], R‐spondin‐2 (RSPO2, Q6UXX9) [277, 426], R‐spondin‐3 (RSPO3, Q9BXY4) [277, 426], R‐spondin‐4 (RSPO4, Q2I0M5) [277, 426]	–	–
Agonists	–	–	angiotensin‐(1‐7) (AGT, P01019) [645] – Mouse	–
Comments	The four R‐spondins can bind to LGR4, LGR5, and LGR6, which specifically associate with Frizzled and LDL receptor‐related proteins (LRPs), proteins that are activated by extracellular Wnt molecules and which then trigger canonical Wnt signalling to increase gene expression [277, 426].	–	–	–