Nomenclature |
calcitonin receptor‐like receptor
|
CGRP receptor
|
AM
1 receptor |
AM
2 receptor |
HGNC, UniProt |
CALCRL, Q16602
|
– |
– |
– |
Subunits |
– |
calcitonin receptor‐like receptor, RAMP1 (Accessory protein) |
calcitonin receptor‐like receptor, RAMP2 (Accessory protein) |
calcitonin receptor‐like receptor, RAMP3 (Accessory protein) |
Potency order of endogenous ligands |
– |
α
‐CGRP (CALCA, P06881) >adrenomedullin (ADM, P35318) ≥adrenomedullin 2/intermedin (ADM2, Q7Z4H4) >amylin (IAPP, P10997) ≥calcitonin (salmon)
|
adrenomedullin (ADM, P35318) >adrenomedullin 2/intermedin (ADM2, Q7Z4H4) >α
‐CGRP (CALCA, P06881), amylin (IAPP, P10997) >calcitonin (salmon)
|
adrenomedullin (ADM, P35318) ≥adrenomedullin 2/intermedin (ADM2, Q7Z4H4) ≥α
‐CGRP (CALCA, P06881) >amylin (IAPP, P10997) >calcitonin (salmon)
|
Endogenous agonists |
– |
β
‐CGRP (CALCB, P10092) [21, 1313], α
‐CGRP (CALCA, P06881) [21, 1313] |
adrenomedullin (ADM, P35318) [21, 1313] |
adrenomedullin (ADM, P35318) [21, 568] |
Antagonists |
– |
olcegepant (pK
i 10.7–11) [462, 753, 754, 929, 1256], telcagepant (pK
i 9.1) [1706] |
– |
– |
Sub/family‐selective antagonists |
– |
– |
AM‐(22‐52) (human) (pK
i 7–7.8) [754] |
– |
Labelled ligands |
– |
[125I]α
CGRP (human) (Agonist), [125I]α
CGRP (mouse, rat) (Agonist) |
[125
I]AM (rat) (Agonist) |
[125
I]AM (rat) (Agonist) |