Skip to main content
. 2017 Oct 21;174(Suppl Suppl 1):S17–S129. doi: 10.1111/bph.13878
Nomenclature calcitonin receptor‐like receptor CGRP receptor AM 1 receptor AM 2 receptor
HGNC, UniProt CALCRL, Q16602
Subunits calcitonin receptor‐like receptor, RAMP1 (Accessory protein) calcitonin receptor‐like receptor, RAMP2 (Accessory protein) calcitonin receptor‐like receptor, RAMP3 (Accessory protein)
Potency order of endogenous ligands α ‐CGRP (CALCA, P06881) >adrenomedullin (ADM, P35318) ≥adrenomedullin 2/intermedin (ADM2, Q7Z4H4) >amylin (IAPP, P10997) ≥calcitonin (salmon) adrenomedullin (ADM, P35318) >adrenomedullin 2/intermedin (ADM2, Q7Z4H4) >α ‐CGRP (CALCA, P06881), amylin (IAPP, P10997) >calcitonin (salmon) adrenomedullin (ADM, P35318) ≥adrenomedullin 2/intermedin (ADM2, Q7Z4H4) ≥α ‐CGRP (CALCA, P06881) >amylin (IAPP, P10997) >calcitonin (salmon)
Endogenous agonists β ‐CGRP (CALCB, P10092) [21, 1313], α ‐CGRP (CALCA, P06881) [21, 1313] adrenomedullin (ADM, P35318) [21, 1313] adrenomedullin (ADM, P35318) [21, 568]
Antagonists olcegepant (pK i 10.7–11) [462, 753, 754, 929, 1256], telcagepant (pK i 9.1) [1706]
Sub/family‐selective antagonists AM‐(22‐52) (human) (pK i 7–7.8) [754]
Labelled ligands [125I]α CGRP (human) (Agonist), [125I]α CGRP (mouse, rat) (Agonist) [125 I]AM (rat) (Agonist) [125 I]AM (rat) (Agonist)