Skip to main content
. 2017 Oct 21;174(Suppl Suppl 1):S17–S129. doi: 10.1111/bph.13878
Nomenclature XCR1 ACKR1 ACKR2 ACKR3 ACKR4 CCRL2
HGNC, UniProt XCR1, P46094 ACKR1, Q16570 ACKR2, O00590 ACKR3, P25106 ACKR4, Q9NPB9 CCRL2, O00421
Endogenous ligands CXCL5 (CXCL5, P42830), CXCL6 (CXCL6, P80162), CXCL8 (CXCL8, P10145), CXCL11 (CXCL11, O14625), CCL2 (CCL2, P13500), CCL5 (CCL5, P13501), CCL7 (CCL7, P80098), CCL11 (CCL11, P51671), CCL14 (CCL14, Q16627), CCL17 (CCL17, Q92583) chemerin C‐terminal peptide, CCL19 (CCL19, Q99731) [101]
Endogenous agonists XCL1 (XCL1, P47992) [564], XCL2 (XCL2, Q9UBD3) [564] CCL2 (CCL2, P13500), CCL3 (CCL3, P10147), CCL4 (CCL4, P13236), CCL5 (CCL5, P13501), CCL7 (CCL7, P80098), CCL8 (CCL8, P80075), CCL11 (CCL11, P51671), CCL13 (CCL13, Q99616), CCL14 (CCL14, Q16627), CCL17 (CCL17, Q92583), CCL22 (CCL22, O00626) CXCL12 α (CXCL12, P48061) [674, 1854], CXCL11 (CXCL11, O14625) CCL19 (CCL19, Q99731) [2085], CCL25 (CCL25, O15444) [2085], CCL21 (CCL21, O00585) [2085]
Comments XCL1 cannot be iodinated, but a secreted alkaline phophatase (SEAP)‐XCL1 fusion peptide can be used as a probe at XCR1. ACKR1 is used by Plasmodium vivax and Plasmodium knowlsei for entering erythrocytes. Several lines of evidence have suggested that adrenomedullin is a ligand for ACKR3; however, classical direct binding to the receptor has not yet been convincingly demonstrated.