Nomenclature |
XCR1
|
ACKR1
|
ACKR2
|
ACKR3
|
ACKR4
|
CCRL2
|
HGNC, UniProt |
XCR1, P46094
|
ACKR1, Q16570
|
ACKR2, O00590
|
ACKR3, P25106
|
ACKR4, Q9NPB9
|
CCRL2, O00421
|
Endogenous ligands |
– |
CXCL5 (CXCL5, P42830), CXCL6 (CXCL6, P80162), CXCL8 (CXCL8, P10145), CXCL11 (CXCL11, O14625), CCL2 (CCL2, P13500), CCL5 (CCL5, P13501), CCL7 (CCL7, P80098), CCL11 (CCL11, P51671), CCL14 (CCL14, Q16627), CCL17 (CCL17, Q92583) |
– |
– |
– |
chemerin
C‐terminal
peptide, CCL19 (CCL19, Q99731) [101] |
Endogenous agonists |
XCL1 (XCL1, P47992) [564], XCL2 (XCL2, Q9UBD3) [564] |
– |
CCL2 (CCL2, P13500), CCL3 (CCL3, P10147), CCL4 (CCL4, P13236), CCL5 (CCL5, P13501), CCL7 (CCL7, P80098), CCL8 (CCL8, P80075), CCL11 (CCL11, P51671), CCL13 (CCL13, Q99616), CCL14 (CCL14, Q16627), CCL17 (CCL17, Q92583), CCL22 (CCL22, O00626) |
CXCL12
α (CXCL12, P48061) [674, 1854], CXCL11 (CXCL11, O14625) |
CCL19 (CCL19, Q99731) [2085], CCL25 (CCL25, O15444) [2085], CCL21 (CCL21, O00585) [2085] |
– |
Comments |
XCL1 cannot be iodinated, but a secreted alkaline phophatase (SEAP)‐XCL1 fusion peptide can be used as a probe at XCR1. |
ACKR1 is used by Plasmodium vivax and Plasmodium knowlsei for entering erythrocytes. |
– |
Several lines of evidence have suggested that adrenomedullin is a ligand for ACKR3; however, classical direct binding to the receptor has not yet been convincingly demonstrated. |
– |
– |