| Nomenclature | C3a receptor | C5a 1 receptor | C5a 2 receptor |
| HGNC, UniProt | C3AR1, Q16581 | C5AR1, P21730 | C5AR2, Q9P296 |
| Potency order of endogenous ligands | C3a (C3, P01024) >C5a (C5, P01031) [41] | C5a (C5, P01031), C5a des‐Arg (C5) >C3a (C3, P01024) [41] | – |
| Endogenous agonists | – | ribosomal protein S19 (RPS19, P39019) [2160] | – |
| Agonists | E7 [43], compound 17 [1644], compound 21 [1643], Ac‐RHYPLWR [707] | N‐methyl‐Phe‐Lys‐Pro‐D‐Cha‐Cha‐D‐Arg‐CO 2H [959, 1035] | – |
| Selective agonists | – | – | P59 (Biased agonist) [396], P32 (Biased agonist) [396] |
| Antagonists | SB290157 (pIC50 7.6) [40], compound 4 (pIC50 5.9) [1643] | avacopan (pIC50 9.7) [125], W54011 (pK i 8.7) [1893], DF2593A (pIC50 8.3) [1380], AcPhe‐Orn‐Pro‐D‐Cha‐Trp‐Arg (pIC50 7.9) [2128], N‐methyl‐Phe‐Lys‐Pro‐D‐Cha‐Trp‐D‐Arg‐CO 2H (pIC50 7.2) [1035] | – |
| Labelled ligands | [125 I]C3a (human) (Agonist) [310] | [125 I]C5a (human) (Agonist) [843] | [125 I]C5a (human) (Agonist) |
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.