| Nomenclature | GnRH 1 receptor | GnRH 2 receptor |
| HGNC, UniProt | GNRHR, P30968 | GNRHR2, Q96P88 |
| Potency order of endogenous ligands | GnRH I (GNRH1, P01148) >GnRH II (GNRH2, O43555) [1342] | GnRH II (GNRH2, O43555) >GnRH I (GNRH1, P01148) (Monkey) [1340] |
| Endogenous agonists | GnRH I (GNRH1, P01148) [1214], GnRH II (GNRH2, O43555) [550, 1214, 1869] | GnRH II (GNRH2, O43555) [1340] – Monkey, GnRH I (GNRH1, P01148) [1340] – Monkey |
| Selective agonists | buserelin [1432], buserelin [1431], buserelin [1431], triptorelin [118], leuprolide [1881], goserelin, histrelin, nafarelin | – |
| Antagonists | iturelix (pK i 9.5) [1664] | – |
| Selective antagonists | cetrorelix (pK i 9.3–10) [119, 120, 1881], abarelix (pK i 9.1–9.5) [1881], degarelix (pK i 8.8) [2017], ganirelix | trptorelix‐1 [1246] – Monkey |
| Labelled ligands | [125 I]cetrorelix (Antagonist) (pK d 9.7) [807], [125 I]triptorelin (Agonist) [435] – Rat, [125 I]buserelin (Agonist) [1076] – Rat, [125 I]GnRH I (human, mouse, rat) (Agonist) | – |
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.