Nomenclature	S1P 1 receptor	S1P 2 receptor	S1P 3 receptor	S1P 4 receptor	S1P 5 receptor
HGNC, UniProt	S1PR1, P21453	S1PR2, O95136	S1PR3, Q99500	S1PR4, O95977	S1PR5, Q9H228
Potency order of endogenous ligands	sphingosine 1‐phosphate>dihydrosphingosine 1‐phosphate>sphingosylphosphorylcholine [46, 1505]	sphingosine 1‐phosphate>dihydrosphingosine 1‐phosphate>sphingosylphosphorylcholine [46, 1505]	sphingosine 1‐phosphate>dihydrosphingosine 1‐phosphate>sphingosylphosphorylcholine [1505]	sphingosine 1‐phosphate>dihydrosphingosine 1‐phosphate>sphingosylphosphorylcholine [2012]	sphingosine 1‐phosphate>dihydrosphingosine 1‐phosphate>sphingosylphosphorylcholine [861]
Agonists	amiselimod phosphate [1887], FTY720‐phosphate [220, 560, 1525], siponimod [1524], AUY954 [1525], AFD(R) [220], etrasimod [254], fingolimod [708]	–	–	–	–
Selective agonists	ozanimod [657, 1274, 1757], ponesimod [176], KRP 203‐phosphate [1851] – Mouse, CYM5181 [657], SEW2871 [1713] – Mouse	–	–	–	–
Antagonists	VPC23019 (pK i 7.9) [419], VPC03090‐P (pK i 7.6–7.7) [972], VPC44116 (pIC50 7.6) [561]	–	VPC44116 (pK i 6.5) [561], VPC23019 (pK i 5.9) [419]	–	–
Selective antagonists	NIBR‐0213 (pIC50 8.6) [1615], W146 (pK i 7.1) [1714]	JTE‐013 (pIC50 7.8) [1515]	–	–	–