Nomenclature	mGlu 1 receptor	mGlu 2 receptor	mGlu 3 receptor	mGlu 4 receptor	mGlu 5 receptor
HGNC, UniProt	GRM1, Q13255	GRM2, Q14416	GRM3, Q14832	GRM4, Q14833	GRM5, P41594
Endogenous agonists	L‐glutamic acid [1574]	L‐glutamic acid [1574]	L‐glutamic acid [1574], NAAG [1750]	L‐glutamic acid [1574]	L‐glutamic acid [1574]
Agonists	–	–	–	L‐AP4 [2138], L‐serine‐O‐phosphate [2138]	–
Selective agonists	–	–	–	LSP4‐2022 [666]	(S)‐(+)‐CBPG (Partial agonist) [1261] – Rat, CHPG [1407]
Antagonists	LY367385 (pIC50 5.1) [364]	–	–	MAP4 (pK i 4.6) [721] – Rat	–
Selective antagonists	3‐MATIDA (pIC50 5.2) [1386] – Rat, (S)‐(+)‐CBPG (pIC50 4.2) [1261] – Rat, (S)‐TBPG (pIC50 4.2) [381] – Rat, AIDA (pA2 4.2) [1387]	PCCG‐4 (pIC50 5.1) [1551] – Rat	–	–	ACDPP (pIC50 6.9) [186]
Allosteric modulators	–	CBiPES (Positive) (pEC50 7) [917], 4‐MPPTS (Positive) (pIC50 5.8) [100, 916, 917, 1731]	–	SIB‐1893 (Positive) (pEC50 6.3–6.8) [1281], MPEP (Positive) (pEC50 6.3–6.6) [1281], PHCCC (Positive) (pEC50 4.5) [1247]	3,3'‐difluorobenzaldazine (Positive) (pIC50 5.6–8.5) [1481, 1482], alloswitch‐1 (Negative) (pIC50 8.1) [1583] – Rat, CDPPB (Positive) (pEC50 7.6–8) [1002, 1180], MTEP (Negative) (pK i 7.8) [228], MPEP (Negative) (pIC50 7.4–7.7) [609, 611], fenobam (Negative) (pIC50 7.2) [1592], SIB‐1893 (Negative) (pIC50 5.9–6.5) [609, 2028], SIB‐1757 (Negative) (pIC50 6–6.4) [609, 2028], CPPHA (Positive) (pIC50 6.3) [1482]
Selective allosteric modulators	BAY 367620 (Negative) (pK i 9.5) [279] – Rat, JNJ16259685 (Negative) (pIC50 8.9) [1104], Ro01‐6128 (Positive) (pK i 7.5–7.7) [1019] – Rat, LY456236 (Negative) (pIC50 6.9) [1160], CPCCOEt (Negative) (pIC50 5.2–5.8) [1183]	Ro64‐5229 (Negative) (pIC50 7) [1031] – Rat, biphenylindanone A (Positive) (pEC50 7) [187]	–	VU0361737 (Positive) (pEC50 6.6) [508], VU0155041 (Positive) (pEC50 6.1) [1468]	VU‐1545 (Positive) (pEC50 8) [429]