Table 2.

Therapeutic potential for targeting SOCS1 pathway.

Pattern	Approach	Function	Mechanism	Implications	Reference
Upregulation of SOCS1	Adenoviral gene transfer	SOCS1 delivery	Upregulating SOCS1	Bleomycin-induced pulmonary fibrosis in SOCS1+/− mice	(99)
	Tyrosine kinase inhibitory peptide	SOCS1 mimetic	Competitive binding to the activation loop of JAK2	Experimental autoimmune encephalomyelitis and multiple sclerosis	(100, 101)
	PS-5	SOCS1-KIR analog	Competitive binding to the activation loop of JAK2	Psoriasis	(79)
	Edratide	SOCS1 inductor: a drug based on the CDR1 sequence of anti-DNA IgG		Systemic lupus erythematosus	(13, 25)

CDR1, complementarity-determining region 1; JAK2, Janus kinase 2; KIR: kinase inhibitory region; SOCS1, suppressor of cytokine signaling 1.