Table 2.
Histological results in fine-needle aspirates from mutated nodules.
| BRAF deletiona | BRAF V600E | BRAF K601E | H-RAS, codon 13 | H-RAS, codon 61 | K-RAS, codon 12 | K-RAS, codon 61 | N-RAS, codon 61 | TERTpC250T | TERTpC228T | N-RAS codon 61 + TERTp C228T | K-RAS codon 12 + TERTp C228T | BRAF K601E + TERTp C250T | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FA | 0 | 0 | 2 | 0 | 1 | 1 | 1 | 8 | 0 | 0 | 0 | 0 | 0 |
| WDT-UMP | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 |
| NIFTP | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 |
| CV-PTC | 1 | 8 | 0 | 1 | 1 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 0 |
| FV-PTC | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 3 | 0 | 0 | 2 | 1 | 0 |
| FTC-MI | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
| FTC-WI | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 2 | 1 | 1 | 1 | 0 | 1 |
| PTC/FTC | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
FA, follicular adenoma; FTC-MI, minimally invasive follicular thyroid carcinoma; FTC-WI, widely invasive follicular thyroid carcinoma; CV-PTC, classical variant of papillary thyroid carcinoma; FV-PTC, follicular variant of papillary thyroid carcinoma; NIFTP, noninvasive follicular thyroid neoplasm with papillary-like nuclear features; PTC/FTC, mixed papillary thyroid carcinoma and follicular thyroid carcinoma; TERTp, TERT promoter; WDT-UMP, well-differentiated tumor of uncertain malignant potential.
aTriplet deletion c.1799_1801delTGA (p.V600_K601>E) without frame-shift.