Skip to main content
. 2017 Oct 16;8:273. doi: 10.3389/fendo.2017.00273

Table 3.

Frequency, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and histological correlations of H-,K-,N-RAS, TERT promoter, and BRAF mutations.

Malignant histology (n = 69/199, 35%) Benign histology (n = 130/199, 65%)
RAS (n = 36/199, 18%)

  • n = 19/36, 53%

  • 6 CV-PTC

  • 7 FV-PTC

  • 1 PTC/FTC

  • 4 FTC-WI

  • 1 FTC-MI

  • n = 17/36, 47%

  • 11 FA

  • 4 WDT-UMP

  • 2 NIFTP

  • Sensitivity: 28%

  • Specificity: 87%

  • PPV: 53%

  • NPV: 69%
TERT promoter (n = 7/199, 4%)

  • n = 7/7, 100%

  • 3 FV-PTC

  • 4 FTC-WI

 n = 0/7, 0%

  • Sensitivity: 10%

  • Specificity: 100%

  • PPV: 100%

  • NPV: 68%
BRAF (n = 15/199, 8%)

  • n = 12/15, 80%

  • 9 CV-PTC

  • 2 FV-PTC

  • 1 FTC-WI

  • n = 3/15, 20%

  • 2 FA

  • 1 NIFTP

  • Sensitivity: 17%

  • Specificity: 98%

  • PPV: 80%

  • NPV: 69%
BRAF K601E (n = 4/199, 2%)

  • n = 1/4, 25%

  • 1 FTC-WI

  • n = 3/4, 75%

  • 2 FA

  • 1 NIFTP

  • Sensitivity: 1%

  • Specificity: 98%

  • PPV: 25%

  • NPV: 65%
BRAF mutations other than K601E (n = 11/199, 6%)

  • n = 11/11, 100%

  • 9 CV-PTC

  • 2 FV-PTC

 n = 0/11, 0%

  • Sensitivity: 16%

  • Specificity: 100%

  • PPV: 100%

  • NPV: 69%
Any mutation (n = 53/199, 27%) n = 33/53, 62% n = 20/53, 38%

  • Sensitivity: 48%

  • Specificity: 85%

  • PPV: 62%

  • NPV: 75%

FA, follicular adenoma; FTC-MI, minimally invasive follicular thyroid carcinoma; FTC-WI, widely invasive follicular carcinoma; PTC, papillary thyroid carcinoma; CV-PTC, classical variant of papillary thyroid carcinoma; FV-PTC, follicular variant of papillary thyroid carcinoma; NIFTP, noninvasive follicular thyroid neoplasm with papillary-like nuclear features; PTC/FTC, mixed papillary thyroid carcinoma and follicular thyroid carcinoma; WDT-UMP, well-differentiated tumor of uncertain malignant potential.