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. Author manuscript; available in PMC: 2018 Oct 15.
Published in final edited form as: Virus Res. 2017 Sep 8;242:1–6. doi: 10.1016/j.virusres.2017.09.001

Table 1.

Protein isoforms of PVR

Isoform Exons encoding protein sequence (Baury et al., 2003) Soluble or Transmembrane (Baury et al., 2003) Location in polarized cells (Ohka et al., 2001) Interaction with Poliovirus (Baury et al., 2003; Koike et al., 1991)
PVRα 1–8 Transmembrane Normally basolateral, tissue dependent Binds to poliovirus, promotes viral entry
PVRβ 1–5, partial 6, 7–8 Soluble Secreted Binds to poliovirus, decreases viral entry
PVRγ 1–5, 7–8 Soluble secreted Binds to poliovirus, decreases viral entry
PVRδ 1–6, alternative C-terminus Transmembrane Non-specific localization, found at both apical and basolateral surface Binds to poliovirus, promotes viral entry