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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Osteoarthritis Cartilage. 2017 Aug 8;25(11):1880–1889. doi: 10.1016/j.joca.2017.07.023

Fig. 3.

Fig. 3

Changes in ATG-5 expression associated with meniscus degeneration. Mouse knee joints were analyzed by a semiquantitative histological grading system for meniscal degeneration in mouse models17. Grades (Gr) are defined from 0 to 4 ranging from healthy normal tissue to severe degeneration. (A) Representative images of mouse knee joints stained with Safranin-O and ATG-5, showing the anterior (A) and posterior meniscus, femur (F) and tibia (T). Original magnification = 10X, Scale bar = 100 μm. (B) Correlation of grading with ATG-5 positive cell density per 100 μm2 area. Results show a significant decrease in ATG-5 positive cells with advancing degeneration. Box and whisker plots (5 mice per group); * = P < 0.05 versus Grade 0 (healthy, normal menisci).