Table 3.

Change in biomarkers over 18 months and associations with change in weight, WOMAC scores and IL-6*

Predictor (change per SD)	Outcome change	Slope (95% CI)	Partial correlation	P-value
Weight	Log-C1M	0.12 (0.08, 0.16)	0.30	<0.0001
Weight	Log-C2M	−0.04 (−0.07, −0.01)	−0.15	0.0065
Weight	Log-C3M	0.08 (0.05, 0.11)	0.28	<0.0001
Weight	Log-CRPM	0.06 (0.03, 0.09)	0.20	0.0004
Log-C1M	WOMAC Pain	0.13 (−0.20, 0.46)	0.04	0.43
Log-C2M	WOMAC Pain	0.09 (−0.24, 0.42)	0.03	0.59
Log-C3M	WOMAC Pain	0.20 (−0.13, 0.53)	0.07	0.24
Log-CRPM	WOMAC Pain	0.26 (−0.07, 0.58)	0.09	0.12
Log-C1M	WOMAC Function	0.65 (−0.38, 1.67)	0.07	0.22
Log-C2M	WOMAC Function	−0.36 (−1.39, 0.67)	−0.04	0.49
Log-C3M	WOMAC Function	1.16 (0.13, 2.19)	0.13	0.027
Log-CRPM	WOMAC Function	1.15 (0.14, 2.16)	0.13	0.026
Log-IL-6	Log-C1M	0.15 (0.11, 0.19)	0.37	<0.0001
Log-IL-6	Log-C2M	−0.03 (−0.06, −0.00)	−0.11	0.045
Log-IL-6	Log-C3M	0.08 (0.05, 0.11)	0.28	<0.0001
Log-IL-6	Log-CRPM	0.07 (0.04, 0.10)	0.23	<0.0001

Model-adjusted estimates of associations between 18-month change in weight (1SD = 8.05 kg) vs. 18-month change in biomarkers or between change in biomarkers and WOMAC pain and function subscales. Associations adjusted for baseline BMI, gender, and baseline value of biomarker.