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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Brain Behav Immun. 2017 Jul 11;66:94–102. doi: 10.1016/j.bbi.2017.07.008

Figure 3. Effect of i.c.v. IL-1RA administration on Kmo expression and behavior.

Figure 3

(A) Effect of SNI on Il1b mRNA expression in the ipsilateral and contralateral prefrontal cortex (Sham n=7, SNI n=11). *= p<0.05 indicates significant difference between groups using two-way ANOVA followed by Bonferroni’s multiple comparison test (side x surgery, F=3.69, p=0.04). (B) Effect of SNI on Il1b mRNA expression in the ipsilateral and contralateral hippocampus (Sham n=8, SNI n=8). (C) Effect of i.c.v. IL-1RA injection (40 ng/4μl/days on day 6 and 7 after surgery) on Kmo mRNA expression in the contralateral hippocampus of Sham and SNI-treated mice (Sham n=6, SNI n=11). *= p<0.05 data were analyzed by two-way ANOVA followed by Bonferroni’s multiple test correction (Surgery x drug, F=4.26, p=0.047). (D) Effect of i.c.v. IL-1RA injection on immobility time (n=5/group). ***= p<0.001 indicate significant difference between groups using two-way ANOVA repeated measures followed by Bonferroni’s multiple test (Surgery x drug, F=23.45, p=0.0002). (E) Effect of SNI on locomotor activity (n=4/group). (F) Effect of i.c.v. IL-1RA injection on mechanical allodynia (n=4/group). ***= p<0.001 indicates difference between Sham + IL-1RA and SNI + IL-1RA groups using two-way ANOVA followed by Bonferroni’s multiple comparison test (Surgery/drug x time, F=8.4, p<0.0001). All data are presented as mean ± SEM.