Table 1. Effect of SNI surgery on kynurenine, quinolinic acid and kynurenic acid concentration in the hippocampus.
Kynurenine (KYN), quinolinic acid (QA), and kynurenic acid (KYNA) concentrations were determined by high-performance liquid chromatography mass spectrometry (HPLC-MS) in contralateral and ipsilateral hippocampus measured by HPLC-MS (Sham n=7, SNI n=10). The kynurenine metabolite concentration were calculated per mg of wet weight. Data are presented as mean ± SEM.
| Sham | SNI | |||
|---|---|---|---|---|
|
| ||||
| Ipsilateral | Contralateral | Ipsilateral | Contralateral | |
|
| ||||
| KYN (pg/mg) | 20.29 ± 0.77 | 17.32 ± 0.82 | 18.49 ± 0.51 | 16.14 ± 0.73 |
| QA (ng/mg) | 14.59 ± 1.06 | 14.87 ± 1.20 | 12.98± 0.50 | 17.67 ± 1.23 |
| KYNA (pg/mg) | 0.75 ± 0.13 | 0.70 ± 0.13 | 0.85 ± 0.12 | 0.60 ± 0.06 |