Table 2.

Summary of some important pros and cons on the neurological wake-up test in traumatic brain injury.

Pro	Con
Detection of changes in neurological status leads to more active management	Induces a stress response with increased ICP, changes in CPP, hypertension
Reduced risk for ventilator-associated pneumonias, reduced ICU stay and less time on ventilator?	No clinical benefit over multimodality monitoring
An important clinical decision tool	Increases brain metabolism and oxygen consumption

ICU, intensive care unit; ICP, intracranial pressure; CPP, cerebral perfusion pressure.