Figure 6.

LPS responses in the lung of WT, Hepc KO and Hepc KOliv mice: Hamp (A), as well as Slc40A1, Fth1, Slc11a2 + IRE, and Hmox1 mRNA levels relative to Ppia, analyzed by real-time PCR in the lung of WT mice (B), Hepc KO mice (C) or Hepc KOliv (D) mice IP injected for 6 h by LPS. Changes are expressed relative to untreated WT or KO mice, respectively. Hamp (E), relative to Ppia, in the lung of Hepc KOliv mice IP injected for 6 h by LPS. This set of results were reproduced using another serie of WT and Hepc KO mice. Error bars represent SEM for n = 3–4 mice in each group. Statistical significance is indicated by asterisks (^*p < 0.05, ^**p < 0.01, ^***p < 0.001).