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. 2017 Oct 17;8:2010. doi: 10.3389/fmicb.2017.02010

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Copyright © 2017 Alves, Waitzberg, de Andrade, dos Santos Aguiar, Reis, Guanabara, Júnior, Ribeiro and Sala.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Liver histopathological analysis in rats after exposure to hypercholesterolemic conditions and prebiotic, probiotic, and/or synbiotic supplementation. (A) NC showing ordinary appearance; (B) PC (hypercholesterolemic diet) showing severe stetatosis in rat hepatocytes (Circle); (C) Prebiotic group showing the presence of mild steatosis in some rat hepatocytes (circle) and the presence of inflammatory cells (arrow); (D) Probiotic group showing severe steatosis in rat hepatocytes (circle); (E) Synbiotic group showing mild stetatosis in some rat hepatocytes (Circle) and the presence of inflammatory cells (arrow). Hematoxylin and eosin stain, 40×.