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. 2017 Oct 17;10:323. doi: 10.3389/fnmol.2017.00323

FIGURE 2.

FIGURE 2

Schematic depiction of timeline of different treatments and measurements. (AI) Mice were administered AlCl3 (40 mg/kg, intraperitoneal) or normal saline once a day for 60 days. Mice were trained (61–64 day) and memory analysis (67th day) was carried out using Morris Water Maze (MWM). Metabolic analysis was carried out on 69th day by infusing [1,6-13C2]glucose, and measuring the labeling of amino acids in tissue extracts using 1H-[13C]-NMR spectroscopy. (AII) Mice were administered Rasa Sindoor (2 g/kg, intragastric) or CMC for 61 to 90 days following 60 days treatments of AlCl3 (40 mg/kg, intragastric) or normal saline. (B) Learning, and (C) Memory of mice following 60 days treatment of AlCl3 (40 mg/kg, intraperitoneal). Memory was assessed using Morris Water Maize test. (D) Immuno-histological depiction of Aβ plaques in AlCl3 treated mice. The arrows point to Aβ plaques in the AlCl3 treated mice.