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. 2017 Oct 17;10:323. doi: 10.3389/fnmol.2017.00323

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Copyright © 2017 Saba, Rajnala, Veeraiah, Tiwari, Rana, Lakhotia and Patel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representative ¹H-[¹³C]-NMR spectra from cortical tissue extracts of AlCl₃ treated mice: (A)¹H-[¹²C+¹³C] represents total concentration of metabolites, (B)¹H-[4x¹³C] depicts ¹³C labeling of metabolites from [1,6-¹³C₂]glucose. Mice were infused with [1,6-¹³C₂]glucose for pre-defined time, and ¹H-[¹³C]-NMR spectra were recorded from cortical tissue extracts. Peak labels are: Ala_C3, alanine-C3; Asp_C3, asparate-C3; GABA_C2, GABA-C2; Gln_C4, glutamine-C4; Glu_C4, glutamate-C4.