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. 2017 Oct 16;11:27. doi: 10.3389/fnint.2017.00027

Figure 2.

Figure 2

Experiment 2, the orofacial affective pain was elevated after injecting the left whisker pad with VZV. Graphs show the percentage of time spent on the light side of the PEAP testing chamber compared to the dark side of chamber by week. A greater percent of time spent on the light side indicated a greater affective pain. The right ventral posterior medial/posterior lateral thalamus (VPM/VPL) was infused with of adeno-associated virus (AAV8)-hSyn-hM4D(Gi)-mCherry and 1 week later the left whisker pad was injected with VZV or the control (MeWo cells without virus). Thirty minutes before PEAP testing the rats were given an injection of either clozapine-n-oxide (CNO) or vehicle (0.9% saline). Testing was completed once a week for 30 min for three consecutive weeks (A–C). The number of rats in each group is shown on the graphs. The animals receiving CNO or saline were reversed from week to week. Asterisk indicates a significant difference of p < 0.05. The values are the mean ± SEM.