Table 5.
Stratification analysis of the four miRNA binding site SNPs and GC susceptibility.
| Variables | rs3748067 | rs10889677 | rs1468488 | rs887796 | ||||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI)a | P a | OR (95% CI)a | P a | OR (95% CI)a | P a | OR (95% CI)a | P a | |
| Age | ||||||||
| ≤50 | 0.66 (0.39, 1.14) | 0.14 | 1.29 (0.87, 1.92) | 0.20 | 0.63 (0.30, 1.34) | 0.23 | 1.25 (0.74, 2.12) | 0.41 |
| >50 | 0.57 (0.41, 0.78) | <0.01 | 1.24 (0.97, 1.58) | 0.09 | 0.90 (0.60, 1.34) | 0.60 | 0.97 (0.72, 1.32) | 0.86 |
| Gender | ||||||||
| Female | 1.15 (0.46, 1.76) | 0.77 | 0.94 (0.56, 1.56) | 0.80 | 1.12 (0.43, 2.97) | 0.82 | 1.08 (0.59, 1.98) | 0.81 |
| Male | 0.55 (0.40, 0.75) | <0.01 | 1.29 (1.02, 1.65) | 0.04 | 0.87 (0.58, 1.31) | 0.51 | 1.08 (0.80, 1.47) | 0.61 |
| Smoking status | ||||||||
| Never | 0.83 (0.55, 1.24) | 0.35 | 1.16 (0.84, 1.60) | 0.36 | 0.80 (0.46, 1.39) | 0.42 | 1.07 (0.72, 1.58) | 0.75 |
| Ever | 0.43 (0.29, 0.63) | <0.01 | 1.40 (1.05, 1.85) | 0.02 | 0.94 (0.59, 1.49) | 0.79 | 1.14 (0.79, 1.65) | 0.47 |
| Drinking status | ||||||||
| Never | 0.60 (0.42, 0.86) | <0.01 | 1.29 (0.99, 1.68) | 0.06 | 0.71 (0.46, 1.08) | 0.11 | 0.85 (0.61, 1.18) | 0.32 |
| Ever | 0.50 (0.31, 0.79) | <0.01 | 1.31 (0.92, 1.87) | 0.13 | 1.52 (0.77, 2.99) | 0.23 | 1.78 (1.12, 2.85) | 0.02 |
| Family history of GC | ||||||||
| No | 0.58 (0.43, 0.79) | <0.01 | 1.33 (1.06, 1.66) | 0.02 | 0.85 (0.58, 1.26) | 0.42 | 0.99 (0.75, 1.32) | 0.96 |
| Yes | 0.53 (0.26, 1.09) | 0.08 | 1.06 (0.61, 1.84) | 0.84 | 1.01 (0.42, 2.45) | 0.98 | 2.01 (0.86, 4.67) | 0.11 |
GC: gastric cancer; SNP: single-nucleotide polymorphism; OR: odds ratio; CI: confidence interval. aOR with 95% CI and P value for logistic regression analysis adjusted for smoking, drinking, and family history of GC.