Table 3.
Step-wise optimization process and model accuracy.
| Optimization cycle | Corrections introduced | R2-value |
|---|---|---|
| Starting point μef = 900*(ln(1+0.35*Z)/M0.411) | - | 0.974 (Figure 1a) |
| 1 (sequence specific Z corrections) | Position specific charge corrections for Asn, Glu, Asn; nearest neighbour effect for Asn, Glu | 0.991 (Figure 1b, c) |
| 2 (mass correction) | Correction related to relative size of the residues in peptide sequence | 0.992 (Figure 1d) |
| 3 (polynomial correction) | Polynomial offset – function of Zc/N | 0.995 (Figure 1e, f) |