Figure 4.

Top 3 overall activating TFs and top 3 overall repressing TFs in the E. coli network. On the left side, the three genes which have more inhibiting links—Crp, Fnr, and Fis—are depicted. At the right side, the top 3 activating genes are shown: Narl, Phob, and Lrp. It can be observed (analogous to the human transcriptional network of Figure 5) that the predominance of the blue links at the left, meanwhile on the right side the red links, are more frequent. In the center of this network, the first neighbors of those 6 genes are shown. It is also possible to observe some small disconnected components at the upper part of the figure.