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Residues altered in BC54-resistant variants of PDE4B2 are located in the active site. A) Y233 (in red) and T407 (in blue) contact the adenosine ring of cAMP in a crystal of PDE4D bound to cAMP (PDB ID: 2PW3) [39]. B) Y233 (in red) and T407 (in blue) contact rolipram in a crystal of PDE4B bound to rolipram (note that both the R- and S-enantiomers of rolipram are shown) (PDB ID: 1RO6 [40]).
