Table 3. Patient factors associated with EQ-5D VAS discordance among patients with improved KCCQ12-os.
| OR (95% CI) | P-value | |
|---|---|---|
| Age | 0.58 | |
| 19-39 | Reference | |
| 40-49 | 0.94 (0.50, 1.75) | |
| 50-59 | 1.25 (0.70, 2.23) | |
| 60-69 | 0.96 (0.54, 1.73) | |
| 70+ | 1.21 (0.64, 2.31) | |
| Female | 1.18 (0.81, 1.72) | 0.39 |
| Body mass index (per +5 kg/m2) | 0.89 (0.79, 1.01) | 0.07 |
| Pulmonary disease | 1.00 (0.59, 1.70) | 0.99 |
| Atrial arrhythmia | 1.11 (0.76, 1.62) | 0.59 |
| Severe diabetes | 1.25 (0.76, 2.05) | 0.37 |
| Major stroke | 0.41 (0.17, 1.01) | 0.05 |
| Peripheral vascular disease | 0.99 (0.49, 2.03) | 0.99 |
| Cancer | 1.15 (0.65, 2.04) | 0.63 |
| Illicit drug use/alcohol abuse | 1.18 (0.73, 1.90) | 0.50 |
| Limited social support | 0.65 (0.30, 1.41) | 0.28 |
| Greater than high school education | 1.13 (0.78, 1.65) | 0.51 |
| Severe depression | 1.21 (0.51, 2.87) | 0.66 |
| Malnutrition/cachexia | 1.02 (0.45, 2.33) | 0.96 |
| # of cardiac hospitalizations in past year | 0.44 | |
| 0-1 | Reference | |
| 2-3 | 1.18 (0.80, 1.74) | |
| 4 or more | 1.33 (0.85, 2.09) | |
| Unknown | 1.41 (0.90, 2.21) | |
| Previous cardiac surgery | 0.72 (0.51, 1.03) | 0.07 |
| Mean arterial pressure (per +10 mmHg) | 1.16 (1.01, 1.34) | 0.04 |
| Pulmonary systolic pressure (per +10 mmHg) | 0.91 (0.80, 1.04) | 0.17 |
| Heart rate (per +10 bpm) | 0.95 (0.85, 1.05) | 0.28 |
| Mod/severe mitral regurgitation | 0.84 (0.59, 1.20) | 0.34 |
| Mod/severe tricuspid regurgitation | 1.13 (0.80, 1.58) | 0.49 |
| Creatinine (per +1 mg/dL) | 1.14 (0.96, 1.36) | 0.14 |
| Albumin (per +1 mg/dL) | 1.21 (0.91, 1.62) | 0.19 |
| Hemoglobin (per +1 mg/dL) | 1.00 (0.92, 1.08) | 0.95 |
| INTERMACS Patient Profile | 0.71 | |
| 1 Critical Cardiogenic Shock | Reference | |
| 2 Progressive Decline | 0.94 (0.48, 1.82) | |
| 3 Stable but Inotrope Dependent | 0.74 (0.37, 1.47) | |
| 4 Resting Symptoms | 1.02 (0.48, 2.15) | |
| 5 Exertion Intolerant | 0.82 (0.25, 2.66) | |
| 6 Exertion Limited | 1.08 (0.13, 9.16) | |
| 7 Advanced NYHA Class 3 | 0.22 (0.01, 4.14) | |
| Baseline KCCQ12-os (per + 10 pts) | <0.001 | |
| 0-<25 (reference) | 1.00 | |
| 25-<50 | 0.66 (0.47, 0.93) | |
| 50-<75 | 0.31 (0.19, 0.51) | |
| 75-100 | 0.03 (0.01, 0.15) | |
| Baseline EQ-5D VAS (per + 10 pts) | <0.001 | |
| 0-<25 (reference) | 1.00 | |
| 25-<50 | 1.62 (0.93, 2.85) | |
| 50-<75 | 7.81 (4.66, 13.10) | |
| 75-100 | 87.39 (46.56, 164.01) | |
| Post-LVAD infection | 1.09 (0.77, 1.56) | 0.62 |
| Post-LVAD respiratory failure | 0.90 (0.51, 1.58) | 0.71 |
| Post-LVAD psychiatric episode | 1.77 (0.94, 3.34) | 0.08 |
| Post-LVAD stroke | 1.53 (0.76, 3.06) | 0.236 |
| Post-LVAD bleeding | 0.90 (0.64, 1.26) | 0.539 |
KCCQ12-os, Kansas City Cardiomyopathy Questionnaire-overall summary score; EQ-5D VAS, EuroQoL-5D Visual Analog Scale