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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Kidney Int. 2017 Jun 24;92(5):1178–1193. doi: 10.1016/j.kint.2017.03.037

Figure 6. Loss of Klf15 in Foxd1+ stromal cells exacerbates AngII-induced fibrosis.

Figure 6

Age-matched 12-week-old Foxd1-Cre Klf15fl/fl and Foxd1-Cre Klf15+/+ mice were concurrently treated with saline or AngII continuous infusion for 6 weeks. (A) All mice were sacrificed and renal cortex fixed for histology. Hematoxylin and Eosin (H&E), Periodic acid-Schiff (PAS), and Masson’s Trichrome staining was performed to evaluate for tubulointerstitial changes. The representative images from 6 mice in each group are shown (X 20). (B) % area fibrosis from Masson’s Trichrome stain is shown. (C) Urine albumin to creatinine (cr), (D) Serum urea nitrogen, and (E) Serum creatinine were measured in all 4 groups 6 weeks post treatment. (n=6, *p<0.05, **p<0.01, Kruskal-Wallis test with Dunn’s post-test).