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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Pharmacol Biochem Behav. 2017 Apr 22;164:32–39. doi: 10.1016/j.pbb.2017.04.006

Figure 2. Illustrative data from studies of cocaine vs. food choice in rhesus monkeys.

Figure 2

Panel A shows cocaine choice dose-effect curves when cocaine was available only during daily choice sessions (“Choice Alone”), during both choice sessions and extended-access sessions (“Choice + Extended Access”), or the first day after termination of extended-access sessions (“Choice + Withdrawal Day 1). Abscissa: Unit cocaine dose in mg/kg/injection, log scale. Ordinate: Percent of total choices allocated to cocaine choice during each component of the choice session. Panel B shows effects of treatment with the kappa opioid receptor antagonist norbinaltorphimine on cocaine choice during withdrawal from extended cocaine access. Abscissa: treatment conditions during extended cocaine access (Ext Acc), after 1 day of withdrawal from extended cocaine access (WD), or after 1 day of withdrawal from extended cocaine access during which subjects were also treated with 10 mg/kg intramuscular norbinaltorphimine. Ordinate: Percent of total choices allocated to heroin choice for the entire choice session. All points show mean ± SEM from four monkeys. Data adapted from Banks and Negus, 2010; Hutsell et al., 2016a.